Evaluation of Anti-Inflammatory and Analgesic Activity of Ananas comosus(L.) Merr. Peel Extracts in Wistar Albino Rats

Background and Aims: Ananas comosus (L.) Merr. (Pineapple) is a tropical plant belongs to the family Bromeliaceae. It is traditionally used to treat various health conditions like inflammation, diabetic condition, cancer, liver diseases etc. The preliminary phytochemical studies of A.comosus peel extract depicted the presence of flavonoids, phenols, tannins, carbohydrates, glycosides, proteins etc. The main aim of this study was to evaluate the anti-inflammatory and analgesic activity of methanolic extract of A. comosus peel in rats.

Methods: induced by sub plantar The anti-inflammatory effect was evaluated by the rat paw edema injection of 100 μL of 1% carrageenan solution in the right hind paw of the rats. Analgesic activity was examined by the acetic-acidinduced writhing response and hot plate test. Both anti-inflammatory and analgesic activity of methanolic extract of peels of A. comosus was studied in Wistar Albino rats at doses of 100, 200 and 300 mg Kg^-1 body weight.

Results: The data showed that the crude extract of peels of A. comosus could reduce the edema in a dose-dependent manner (P<0.05). The result of 300 mg Kg-1 of the extract were more significant and comparable with the effect of Diclofenac sodium. Also application of different doses of crude extract of peels of A. comosus had significant antinociceptive effects in both animal models.

Conclusion: Based on the results from the present study it is concluded that the methanolic extract of A. comosus peel possesses significant anti-inflammatory activity in animal models. More studies are required to clarify the active components responsible for the anti-inflammatory and analgesic activity.