Hepatoprotective and Antioxidant Effect of Polygonum persicaria linn. and its Active Principle on Carbon Tetrachloride Induced Toxicity in Rats

Objective: The current examination was done to examine the hepatoprotective impact and antioxidant prevention of
the aqueous extract of the roots of Polygonum persicaria and its active principle i.e. tannic acid in rats treated with CCl₄
(1.5 ml/kg, i.p.).

Methods: Twenty albino Wister rats were dispensed to five gathering (control, CCl₄ prompted hepatotoxicity and
hepatotoxicity with P. persicaria and tannic acid and one gathering goes about as a standard treated with silymarin 100
mg/kg. Rats were scarified following 14 days. Toxicity was performed utilizing 12 rats. They were randomly isolated
into three gatherings (control and rewarded with 200 mg/kg (B.wt) of P. persicaria (o.p) & 200 mg/kg (B.wt) of tannic
acid (o.p).

Results: Concentrate of P. persicaria and tannic acid at the tried dosages reestablished the degrees of liver
homogenate enzymes (glutathione peroxidase, glutathione-S transferase, superoxide dismutase and catalase
enzymes essentially and reversed the biochemical alterations. This investigation proposes that tannic acid has a
progressively liver defensive impact in comparison of P. persicaria against carbon tetrachloride-initiated
hepatotoxicity and have antioxidant activities and displayed moderate anticancer activity towards cell viability at
higher concentration. Liver damage was confirmed by the histological changes.

Conclusion: The results from this assessment demonstrate hepatoprotective action of P. persicaria and tannic acid
against CCl₄- prompted liver toxicity in rats that might be associated with its antioxidant properties.