Conceivable Role of Immunity Booster Herbal Drugs in Covid-19

Background: The outbreak of the novel Coronavirus disease (COVID-19) emerged in December 2019, from (Wuhan)
China has now become an emergency of major international concern. The virus is known as Corona due to the presence
of crown like spikes on its surface. It is a highly contagious disease which is believed to be the mutated form of SARS
(2002) and MERS (2012) virus, causing approximately 3.7% mortality rate worldwide. The main cause of mortality is
clusters of severe respiratory illness similar to SARS. The transmission of novel Corona virus occurs via droplets of
human sputum, contaminated hands and surfaces. The incubation time has been described to be 02- 14 days and for
the treatment of COVID-19, early diagnosis, quarantine, and supportive care are essential for patients.

Aim: Focusing the possible role of immunity boosting herbal drugs to develop a better immunity which helps to
protect humans from COVID-19 infections.

Methods: Immunity boosting herbal drugs and their purified products have shown positive results and may have role
as a supportive treatment against COVID-19 infections. Some herbal drugs having immunity boosting effects are
mentioned below with their therapeutic actions:

Herbal Drug	Mechanism of Action	Therapeutic Effects	Reference
Allium sativum	Higher concentration of sulphur compounds	Immunomodulator	https://www.ncbi.nlm.rah.gov/pmc/articiles/PMC4032839/#ref16
(Garlic)	activates natural killer cell activity
Withania somnufera	Sitoindoside IX and Sitoindoside X helps	Immunomodulator	Bioactive PhytosterolConjugates, Part-7, Ghosalet al. (1989)
(Ashwagandha)	defending body’s immunity by improving
	cell-mediated immunity
Curcuma longa	Curcumin (diferuloylmethane) can modulate	Immunomodulator	http://pubmed.ncbi.nlm.nih.gov/172 11725/
(Haldi)	the activation of T cells, B cells, macrophages,
	neutrophils, natural killer cells, and dendritic
	cell causing immunomodulatory effect
Ocimum sanctum	Eugenol, flavonoids can induce interferon	Anti-inflammatory	Shah B, Seth A.K, Textbook of Pharmacognosy and Phtyo chemistry, (2014), pg:588-589
(Tulsi)	productions leads to anti-inflammatort
	action

Result: The drugs mentioned above may give promising protection against COVID-19 infection if research is focused
on these herbals. Chawanprash and Triphala are well known immunity boosting formulations available in the market.
Apart from these mentioned drugs, Zingiber Officinalis, Glycyrhizza glabra and Adhatoda vesica may play their
therapeutic roles for COVID-19 by treating lungs associated diseases.

Conclusion: Immunity booster herbals could be a valuable pool for the development of active compounds for
protection against COVID-19 infection and may contribute to the mitigation of the spread of the pandemic. We must
encourage the research on these immunity boosting herbals and their products to tackle this pandemic.