Cannabis sativa Plant and its Viable Antifungal Activity

Background and aims: Cannabis sativa has a long history of human use. It has several phytoconstituents namely
cannabinoids, terpenoids, and phenolic compounds. Among these, cannabinoids reflect the most studied class of
molecules. Tetrahydrocannabinol and cannabidiol are the major cannabinoids. Cannabinoids show their action by
acting on the endocannabinoid system found in human body. It possesses potent antifungal and antimicrobial
activity. Researches have shown that C. sativa has been effective in killing Candida albicans and Aspergilus niger
without causing drug resistance. In one study, it was reported that acidic extract of C. sativa was effective in showing
antifungal activity at very low concentrations when compared to Nystatin. In a recent study, ZnO and Ag doped
nanoparticles were prepared from Cannabis sativa leaf extract. They were found to be effective against fungal
(Fusarium spp. and Rosellinia necatrix) and microbial strains. It's reclassification in 2018 from Schedule 1 to Schedule 2
made it possible to be prescribed in disease conditions.

Methods: Up to date data obtained from various reliable resources has been used. It includes Scopus, Web of Science,
Medline via PubMed, Google Scholar, several reviews and research articles, books, clinical trials and government
reports.

Results: Extensive studies indicated C. sativa plant’s antifungal potential along with its other established medicinal
effects. It displays antifungal activity and thus can also be used on commercial level. It was also observed that cannabis
lacks supportive clinical data and more studies are needed to be conducted for harnessing its full antifungal potential.

Conclusions: Despite being a plant of medicinal importance, C. sativa is still considered as a threat to society due to its
abuse potential. However, under proper guidance and in proper concentration it can prove to be a drug of great
importance with least toxicity.