An Overview on Plant Derived Antimicrobial Peptides: Potential Antibiotics Against Resistant Pathogens

Background: Like any other living organism, plants too undergo attacks of insects, fungi and bacteria. These
challenges result in the development of an efficient defense mechanism, through the synthesis of secondary
metabolites, which includes antimicrobial peptides (AMPs). Also, AMPs can be isolated from various plants and parts
of the plant like, leaves, roots, seeds, flowers & fruits.

Aim: To know the different antimicrobial peptides isolated from the plants and to provide an outlook on their
biotechnological potential.

Methods: AMPs have the ability to interact with several targets in Gram positive and negative bacteria, protozoa,
yeast, fungi and viruses. Also, some infections show high resistance to traditional antibiotics, in that case AMPs are
promising due to their broad spectrum antibacterial activity. Among them Colistin and Polymixin B, are widely used in
clinical practice (Table 1).

Table 1:

Classes of plant derived AMPs, source & name of peptides:

Class	Source	Peptide	Antimicrobial Activity
Defensin	Avocado (P. americana)	PaDef	E. coli
	Fruit peppers (C. annuum var. Yolo Wonder)	J1	S. cerevisiae
Lipid transfer proteins (LTPs)	Chili pepper (C. annuum L.)	Ca-LTP1	C. tropicalis
2S Albumin	Passion fruit (P. alata Curtis)	Pa-AFP1	C. gloeosporioides
Glycine rich protein	Guava seeds (P. guajava)	Pg-AMP1	Klebsiella sp.
Snakin	Jujuba fruits (Z. jujuba)	Snakin-Z	A. Niger
Napin	Coconut water (Trapa natans)	Tn-AFP1	F. oxysporum
Unclassified	AMPs from fruits	Cn-AMP3	S. aureus

Result: AMPs defense mechanism makes them the new antibiotic substances, also the defensins used in agroproducts
with antifungal activity will be used for growth of agricultural production. AMPs can also be associated in
inflammatory response, infectious diseases, immunosuppressive and tumoral diseases. The broad spectrum
antimicrobial activity in some peptides suggest their potential for treating cancer & parasitic infections.

Conclusion: Storage organs and reproductive tissues of fruits are responsible for the production and accumulation of
AMPs as the first line of defense. The AMPs promising activity as antimicrobials could be used in synergism with other
drugs, chemical combinations and modifications to improve AMPs bioactivity.